Colts Coach Chuck Pagano confirmed Monday that Luck would miss the game.
Luck has yet to make an appearance during the regular season and the Colts offense continues to struggle, mainly due to the lackluster quarterback play.
Jacoby Brissett will make his 2nd start for the Colts.
Fantasy owners should look to trade Luck as it appears he is not close to a return.
On the flip side, Luck may be a good stash for next season and worth the roster spot should he be available on your free agent wire.